Ward B S, Glazier J D, Sibley C P, Boyd R D
Department of Child Health, University of Manchester, St Mary's Hospital, UK.
Exp Physiol. 1998 May;83(3):361-70. doi: 10.1113/expphysiol.1998.sp004119.
Feto-maternal vascular (PD(F-M)) and amniotic maternal (PD(A-M)) potential differences were measured simultaneously on seven occasions in six conscious pigs of 100-106 days gestation. Resting values of PD(F-M) and PD(A-M) were not significantly different although the range was wide. Fetal intravascular injection of 20 microg adrenaline, but not of saline, was associated with a prompt reversible change, of equal magnitude, in both PD(F-M) and PD(A-M). In some experiments polarity was reversed. Feto-amniotic potential difference did not change. There was no change in fetal plasma K+ and Na+ concentrations. Because of the simultaneous and equal alterations in PD(F-M) and PD(A-M) following adrenaline and the anatomical configuration of the pig conceptus, we conclude that the catecholamine modifiable component of PD(F-M) is generated by electrogenesis in the pig placenta, probably by its chorionic (trophoblastic) cell layer.
在妊娠100 - 106天的6头清醒母猪身上，7次同时测量母胎血管（PD(F - M)）和羊膜 - 母体（PD(A - M)）电位差。尽管范围较宽，但PD(F - M)和PD(A - M)的静息值无显著差异。向胎儿血管内注射20微克肾上腺素而非生理盐水，会使PD(F - M)和PD(A - M)迅速发生大小相等的可逆变化。在一些实验中极性会反转。胎儿 - 羊膜电位差没有变化。胎儿血浆钾离子和钠离子浓度没有变化。由于注射肾上腺素后PD(F - M)和PD(A - M)同时且同等程度地改变，以及猪胚胎的解剖结构，我们得出结论，PD(F - M)中儿茶酚胺可调节成分是由猪胎盘，可能是其绒毛膜（滋养层）细胞层的电发生产生的。
