Ren D, Huang W, Yang M
General Hospital of Air Force, Beijing.
Zhonghua Fu Chan Ke Za Zhi. 1997 Aug;32(8):480-2.
To supply evidence of relationship between pregnancy induced hypertension (PIH) and 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine receptor (5-HTR) synthesized by placental villi.
Five normal placentas and 15 placentas of PIH were used for studying localization and quantification of 5-HT and 5-HTR in placental villi by using immunohistochemical and in situ quantitative methods.
Syncytiotrophoblasts and capillary endothelium in placental villi of control group showed 5-HT and 5-HTR positive immunoreaction, but in placental villi of group with PIH, syncytiotrophoblasts appeared 5-HT and 5-HTR weak positive immunoreaction and capillary endothelium appeared 5-HT and 5-HTR weak positive or negative immunoreaction. The results of in situ quantitation showed that the content of 5-HT and 5-HTR in placental villus syncytiotrophoblasts of group with PIH were significantly lower than those in the control group.
The content of 5-HT and its receptor in placenta may be related to PIH.
提供妊娠高血压综合征（PIH）与胎盘绒毛合成的5-羟色胺（5-HT）及5-羟色胺受体（5-HTR）之间关系的证据。
采用免疫组织化学和原位定量方法，对5例正常胎盘和15例PIH胎盘进行研究，以确定胎盘绒毛中5-HT和5-HTR的定位及定量。
对照组胎盘绒毛的合体滋养层细胞和毛细血管内皮显示5-HT和5-HTR阳性免疫反应，但PIH组胎盘绒毛中，合体滋养层细胞呈现5-HT和5-HTR弱阳性免疫反应，毛细血管内皮呈现5-HT和5-HTR弱阳性或阴性免疫反应。原位定量结果显示，PIH组胎盘绒毛合体滋养层细胞中5-HT和5-HTR的含量明显低于对照组。
胎盘中5-HT及其受体的含量可能与PIH有关。
