Bao P, Wu Y, Gu Q
First People's Hospital of Shanghai.
Zhonghua Fu Chan Ke Za Zhi. 1997 Nov;32(11):649-51.
To investigate the effect of second-trimester maternal serum markers AFP, beta-hCG, uE3, for prenatal screening of the fetal defects.
In 677 women the triple markers were measured. Some factors that may affect the testing such as maternal weight, gestational age, were adjusted on analyzing the result of the testing. Each woman, who underwent the triple screening, will be followed up until her fetus was delivered.
Among the women who were screened, 11 patients who presented at least one marker positive were identified as having an abnormal fetus, and the positive rate was 1.6%. While 32 women were confirmed to be false positive with a rate of 4.7%. Another 11 women had fetal demise on second-trimester, which had been proved to be not caused by fetal abnormality.
Maternal triple serum markers may take as a routine protocol for prenatal screening of the fetal defects.
探讨孕中期母体血清标志物甲胎蛋白（AFP）、β-人绒毛膜促性腺激素（β-hCG）、游离雌三醇（uE3）用于胎儿缺陷产前筛查的效果。
对677名女性进行三项标志物检测。在分析检测结果时，对一些可能影响检测的因素，如母体体重、孕周进行了校正。每位接受三联筛查的女性将被随访至胎儿分娩。
在接受筛查的女性中，11例至少一项标志物呈阳性的患者被确定为胎儿异常，阳性率为1.6%。32名女性被确认为假阳性，假阳性率为4.7%。另有11名女性在孕中期出现胎儿死亡，经证实并非由胎儿异常引起。
母体血清三联标志物可作为胎儿缺陷产前筛查的常规方案。
