Pan T, Chau S, Von Planta M, Studer W, Scheidgger D
Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical University, Wuhan. Wuhan.
J Tongji Med Univ. 1997;17(2):94-7. doi: 10.1007/BF02888243.
The effect of a pure alpha-adrenergic agent, methoxamine on ventricular fibrillation (VF) amplitude and the relation between hemodynamic parameters and survival in a rodent cardiopulmonary resuscitation (CPR) model were studied. Our results suggested that: 1) VF amplitude decreased during untreated VF, but it increased during pericardial chest compression: 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP) but not VF amplitude, and the survival also increased due to elevation of CPP; and 3) all surviving animals with successful defibrillation had a higher VF amplitude.
研究了一种纯α-肾上腺素能药物甲氧明对心室颤动（VF）幅度的影响，以及在啮齿动物心肺复苏（CPR）模型中血流动力学参数与生存率之间的关系。我们的结果表明：1）在未经处理的VF期间VF幅度降低，但在心包胸外按压期间增加；2）甲氧明显著提高平均主动脉压（MAP）和冠状动脉灌注压（CPP），但不提高VF幅度，并且由于CPP升高生存率也增加；3）所有成功除颤的存活动物具有更高的VF幅度。
