Pan T, Zhou S, Studer W, von Planta M, Scheidegger D
Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1997;17(4):244-6. doi: 10.1007/BF02895630.
The purpose of this study was to investigate the effect of non-adrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2 (ETCO2) during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasopresin (AVP) and angiotension-II (ANG-II), but not by endothelin-1 (ET-1); 2) ETCO2 prior to defibrillation was decreased significantly by a pure alpha 1 adrenergic agents, methoxamine and were increased significantly by non-adrenergic agents, ANG-II and ET-1 during rodent CPR; 3) a significant positive correlation between ETCO2 and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-II have similar effect on resuscitability during rodent CPR.
本研究的目的是在啮齿动物模型中研究非肾上腺素能药物对心肺复苏（CPR）及CPR期间呼气末二氧化碳（ETCO2）的影响。我们的结果表明：1）注射药物后，甲氧明、精氨酸加压素（AVP）和血管紧张素II（ANG-II）可显著提高冠状动脉灌注压（CPP），但内皮素-1（ET-1）无此作用；2）在啮齿动物CPR期间，一种纯α1肾上腺素能药物甲氧明可显著降低除颤前的ETCO2，而非肾上腺素能药物ANG-II和ET-1可使其显著升高；3）在AVP组中观察到ETCO2与CPP之间存在显著正相关，表明AVP对肺循环影响较小；4）甲氧明、AVP和ANG-II在啮齿动物CPR期间对复苏能力的影响相似。
