Kirk R S, Lewis J W
Division of Biology, School of Biological Sciences, University of London, Egham, Surrey, UK.
J Helminthol. 1998 Mar;72(1):33-8. doi: 10.1017/s0022149x00000948.
The histopathological response of carp to Sanguinicola inermis was investigated by serial sectioning laboratory infected fish up to 90 days post infection (d p.i.). Juvenile flukes and adults caused mechanical damage to tissues during invasion and migration up to 28 d p.i. Adults partially occluded blood vessels and may have reduced blood circulation. In the initial phase of egg production (28-42 d p.i.), eggs and emigrating miracidia in gill tissue caused breakdown of vascular integrity, necrosis, hyperplasia, haemorrhage and eosinophilic infiltration of epithelial tissue. After 42 d p.i. the host granulomatous inflammatory response encapsulated eggs lodged in the gills, visceral sites and connective tissue displacing normal tissue. Encapsulation and subsequent degradation of eggs and miracidia within granulomata was highly developed by 90 d p.i. Laboratory infections of S. inermis can induce respiratory distress and therefore impair respiration of fish. The parasite also caused pathological changes in osmoregulatory, excretory and haemopoietic tissue and may impair function in these organ systems.
通过对实验室感染的鲤鱼进行连续切片，研究了鲤鱼对无棘血居吸虫的组织病理学反应，感染时间长达感染后90天（dpi）。幼体吸虫和成虫在入侵和迁移过程中（直至感染后28天）对组织造成机械损伤。成虫部分阻塞血管，可能会减少血液循环。在产卵初期（感染后28 - 42天），鳃组织中的虫卵和逸出的毛蚴导致血管完整性破坏、坏死、增生、出血以及上皮组织嗜酸性粒细胞浸润。感染后42天，宿主的肉芽肿性炎症反应包裹了沉积在鳃、内脏部位和结缔组织中的虫卵，取代了正常组织。到感染后90天，肉芽肿内虫卵和毛蚴的包裹及随后的降解过程高度发展。无棘血居吸虫的实验室感染可诱发呼吸窘迫，从而损害鱼类的呼吸。该寄生虫还会引起渗透调节、排泄和造血组织的病理变化，并可能损害这些器官系统的功能。
