Szechiński J, Wiland P
Zakład Reumatologii Akademii Medycznej, Okregowego Szpitala Kolejowego, Wrocławiu.
Pol Arch Med Wewn. 1997 Dec;98(12):536-41.
N-acetyl-beta-D-glucosaminidase (NAG) urine activities of 63 patients with stable and unstable chronic renal failure have been investigated. The values of NAG activity obtained from these patients were compared with NAG activity of 33 normal controls. Abnormal NAG values (> 70 nmol/mg of creatinine) were found in 60 (95.2%) patients with chronic renal failure and the median of all values was 327.8 nmol/mg of creatinine. It was 14-fold greater than the median of values for normal controls. There were any significant differences of NAG values between the patients with massive proteinuria (> 1.5 g/24 h), moderate proteinuria and those without 24 hour proteinuria or non-significant proteinuria (respectively 423.5 +/- 286.3 vs 414.4 +/- 334.8 vs 453.0 +/- 451.3 nmol/mg of creatinine). There was no significant difference between the two subgroups of patients with NAG values above and below 280 nmol/mg of creatinine in age, gender, serum urea and uric acid levels. However, the incidence of patients with NAG values higher than 280 nmol/mg of creatinine was statistically significant in unstable course of renal insufficiency and raised serum creatinine levels. It is suggested that the measurement of NAG excretion may be helpful to monitor unstable process in renal failure.
对63例稳定期和不稳定期慢性肾衰竭患者的尿N - 乙酰 -β - D - 氨基葡萄糖苷酶（NAG）活性进行了研究。将这些患者的NAG活性值与33名正常对照者的NAG活性进行了比较。在60例（95.2%）慢性肾衰竭患者中发现NAG值异常（>70 nmol/mg肌酐），所有值的中位数为327.8 nmol/mg肌酐。这比正常对照者值的中位数高14倍。大量蛋白尿（>1.5 g/24 h）患者、中度蛋白尿患者以及无24小时蛋白尿或微量蛋白尿患者的NAG值之间无显著差异（分别为423.5±286.3 vs 414.4±334.8 vs 453.0±451.3 nmol/mg肌酐）。NAG值高于和低于280 nmol/mg肌酐的两组患者在年龄、性别、血清尿素和尿酸水平方面无显著差异。然而，在肾功能不全的不稳定病程和血清肌酐水平升高时，NAG值高于280 nmol/mg肌酐的患者发生率具有统计学意义。提示测定NAG排泄量可能有助于监测肾衰竭的不稳定过程。
