Sinclair S A, Sviland L, Natarajan S
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
Br J Dermatol. 1998 Apr;138(4):692-4. doi: 10.1046/j.1365-2133.1998.02188.x.
Cutaneous angiosarcoma is a rare aggressive tumour of capillary and lymphatic endothelial cell origin. It presents as multiple purple and red papules and nodules on the head and neck or the extremities. We report an 86-year-old woman with angiosarcoma arising on her chronically lymphoedematous right leg. The lymphoedema, secondary to chronic immobility, had developed gradually over 40 years. No other family members had lymphoedema. The patient presented with a plaque of friable tumour tissue on the lower right leg and dorsum of the foot, and satellite lesions on the knee and groin which initially appeared to be petechial haemorrhages. The satellite lesions in the groin grew into tumour nodules. There was no evidence of a preceding malignancy, nor any operative intervention to the affected limb or abdomen. Histological examination of all tumour specimens revealed moderately to poorly differentiated angiosarcoma. She died within 5 months of the first appearance of the skin nodules.
皮肤血管肉瘤是一种罕见的侵袭性肿瘤，起源于毛细血管和淋巴管内皮细胞。它表现为头颈部或四肢出现多个紫红色丘疹和结节。我们报告一例86岁女性，其慢性淋巴水肿的右腿发生血管肉瘤。继发于长期活动受限的淋巴水肿已逐渐发展了40年。没有其他家庭成员患有淋巴水肿。患者右小腿下部和足背出现一块易碎的肿瘤组织斑块，膝关节和腹股沟有卫星病灶，最初看似瘀点出血。腹股沟的卫星病灶发展成肿瘤结节。没有先前恶性肿瘤的证据，也没有对患肢或腹部进行任何手术干预。所有肿瘤标本的组织学检查显示为中分化至低分化血管肉瘤。她在皮肤结节首次出现后的5个月内死亡。
