Varga-Weisz P D, Becker P B
Marie Curie Research Institute, Oxted, Surrey, UK.
Curr Opin Cell Biol. 1998 Jun;10(3):346-53. doi: 10.1016/s0955-0674(98)80010-0.
Chromatin has shifted into the focus of attention as a key to understanding the regulation of nuclear processes such as transcription. Protein machines have been described that use the energy of ATP to render chromatin dynamic and hence active, but which may also be involved in chromatin assembly. The discovery of three different Drosophila nucleosome remodeling complexes that contain imitation switch (ISWI), an ATPase with a high degree of sequence conservation from yeast to human, points to a central function of this ATPase in chromatin dynamics.
染色质已成为关注焦点，是理解诸如转录等核过程调控的关键。已描述了一些蛋白质机器，它们利用ATP的能量使染色质具有动态性从而具有活性，但也可能参与染色质组装。发现三种不同的果蝇核小体重塑复合体，它们含有模仿开关（ISWI），这是一种从酵母到人类都具有高度序列保守性的ATP酶，表明该ATP酶在染色质动力学中具有核心功能。
