TCF：转录激活因子还是转录抑制因子？
TCF: transcriptional activator or repressor?
作者信息
Bienz M
机构信息
MRC Laboratory of Molecular Biology, Cambridge, UK.
出版信息
Curr Opin Cell Biol. 1998 Jun;10(3):366-72. doi: 10.1016/s0955-0674(98)80013-6.
PMID:9640538
Abstract
T cell factor, or TCF, has been identified as the transcriptional response factor activated by Wnt-1 and Wingless signalling. TCF is thought to be a potent architectural factor which facilitates assembly of multiprotein enhancer complexes. Its deregulation in the colonic epithelium, and in other cells, leads to cancer. This raises the question of how TCF is kept inactive in unstimulated cells.
摘要
T细胞因子（TCF）已被确定为受Wnt-1和无翅信号激活的转录反应因子。TCF被认为是一种强大的结构因子，可促进多蛋白增强子复合物的组装。其在结肠上皮细胞和其他细胞中的失调会导致癌症。这就提出了一个问题，即TCF在未受刺激的细胞中是如何保持无活性的。
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