Das Bhabajyoti, Das Manas, Kalita Anuradha, Baro Momita Rani
Department of Zoology, Animal Physiology and Biochemistry Laboratory, Gauhati University, Guwahati, 781014 Assam India.
J Diabetes Metab Disord. 2021 Aug 3;20(2):1871-1882. doi: 10.1007/s40200-021-00862-8. eCollection 2021 Dec.
Diabetes has become a major killer worldwide and at present, millions are affected by it. Being a chronic disease it increases the risk of other diseases ranging from pulmonary disorders to soft tissue infections. The loss of insulin-producing capacity of the pancreatic β-cells is the main reason for the development of the disease. Obesity is a major complication that can give rise to several other diseases such as cancer, diabetes, etc. Visceral adiposity is one of the major factors that play a role in the development of insulin resistance. Obesity causes a chronic low-grade inflammation in the tissues that further increases the chances of developing diabetes. Several pathways have been associated with the development of diabetes due to inflammation caused by obesity. The Wnt pathway is one such candidate pathway that is found to have a controlling effect on the development of insulin resistance. Moreover, the pathway has also been linked to obesity and inflammation. This review aims to find a connection between obesity, inflammation, and diabetes by taking the wnt pathway as the connecting link.
糖尿病已成为全球主要杀手，目前数百万人受其影响。作为一种慢性病，它会增加从肺部疾病到软组织感染等其他疾病的风险。胰腺β细胞胰岛素分泌能力丧失是该疾病发展的主要原因。肥胖是一种主要并发症，可引发其他多种疾病，如癌症、糖尿病等。内脏脂肪过多是导致胰岛素抵抗的主要因素之一。肥胖会导致组织慢性低度炎症，进而增加患糖尿病的几率。由于肥胖引起的炎症，多种途径与糖尿病的发展相关。Wnt途径就是这样一种候选途径，被发现对胰岛素抵抗的发展具有控制作用。此外，该途径还与肥胖和炎症有关。本综述旨在以Wnt途径为连接点，探寻肥胖、炎症与糖尿病之间的联系。
