Guzmán-Silva M A
Department of Pathology, Fluminense Federal University, Niteroi, RJ, Brasil.
Acta Cient Venez. 1997;48(3):134-8.
In order to identify the cellular basis of the gerbil skin unresponsiveness to two-stage carcinogenesis, it was studied the effect of an initiating dose of carcinogen on the biological behaviour of gerbil skin. Treatment of adult gerbil epidermal cells either in vivo or in vitro with 3-methylcholanthrene yielded cells which were resistant to terminal differentiation induced by calcium. These results support the concept derived from the mouse model system of skin carcinogenesis in which initiation is associated with an altered program of epidermal differentiation. The results also suggest that relative resistance of gerbil skin to two-stage carcinogenesis is related to promotion stage.
为了确定沙鼠皮肤对两阶段致癌作用无反应性的细胞基础，研究了致癌剂起始剂量对沙鼠皮肤生物学行为的影响。用3-甲基胆蒽对成年沙鼠表皮细胞进行体内或体外处理，产生了对钙诱导的终末分化具有抗性的细胞。这些结果支持了源自皮肤癌发生小鼠模型系统的概念，即在该系统中起始与表皮分化程序改变相关。结果还表明，沙鼠皮肤对两阶段致癌作用的相对抗性与促进阶段有关。
