Rascón A
Laboratorio de Señalización Celular, Facultad de Ciencias, Universidad Central de Venezuela, Caracas.
Acta Cient Venez. 1997;48(3):145-53.
During the last years there have been major advances in the knowledge of cyclic nucleotide phosphodiesterases. Particularly, referred to the presence of multiple different isozymes. Seven different phosphodiesterase gene families, have been described in mammalian tissues, containing several distinct genes, most of them expressed in different tissues as functionally unique splice variants. This article includes various aspects of the currently accepted nomenclature, structure and function of each family of phosphodiesterases. Finally, a brief discussion of the presence and role of these enzymes in the cell proliferation and differentiation processes, in parasites of the Trypanosmatidae family, is provided.
在过去几年里，环核苷酸磷酸二酯酶的知识有了重大进展。特别是，涉及多种不同同工酶的存在。在哺乳动物组织中已描述了七个不同的磷酸二酯酶基因家族，包含几个不同的基因，其中大多数在不同组织中作为功能独特的剪接变体表达。本文涵盖了目前公认的各磷酸二酯酶家族的命名、结构和功能的各个方面。最后，简要讨论了这些酶在锥虫科寄生虫的细胞增殖和分化过程中的存在及作用。
