Steinbrunner R L, Brown C E, Legan J J, Kafrawy A H
Department of Restorative Dentistry, Indiana University School of Dentistry, Indianapolis 46202-5186, USA.
J Endod. 1998 May;24(5):335-42. doi: 10.1016/S0099-2399(98)80130-1.
Biocompatibility and osteogenic potential of two calcium phosphate cements (G-5 and G-6) and Super-EBA were investigated by subcutaneous and intraosseous implantation in 90 rats. Reactions were studied microscopically at 15, 30, and 60 days after implantation. Super-EBA was well tolerated by both soft and hard tissues. G-5 was highly biocompatible with resorption and bone replacement at intraosseous implantation sites. G-6 promoted moderate inflammation and a foreign body giant cell response over the 60-day study period. None of the materials elicited osteogenesis or dystrophic calcification at the subcutaneous implantation sites.
通过对90只大鼠进行皮下和骨内植入，研究了两种磷酸钙骨水泥（G-5和G-6）以及Super-EBA的生物相容性和成骨潜力。在植入后15、30和60天进行显微镜下反应研究。Super-EBA在软组织和硬组织中均具有良好的耐受性。G-5在骨内植入部位具有高度生物相容性，伴有吸收和骨替代。在60天的研究期内，G-6引发了中度炎症和异物巨细胞反应。在皮下植入部位，没有一种材料引发骨生成或营养不良性钙化。
