Pertot W J, Stephan G, Tardieu C, Proust J P
Unité Interface Matrice Extracellulaire Biomatériaux-EA 1787, Université de la Méditerranée, U.F.R. d'Odontologie, Marseille, France.
J Endod. 1997 May;23(5):315-9. doi: 10.1016/S0099-2399(97)80413-X.
The purpose of this study was to compare the intraosseous biocompatibility of Dyract, a new hydrophilic glass-ionomer cement, to that of Super EBA. Twenty-four New Zealand rabbits were anesthetized, one leg was shaved, the femur exposed, and two holes were drilled through the cortical plate. The materials were loaded into silicone carriers and inserted into the femur. Half of the rabbits were killed 4 weeks after implantation and the other half at 12 weeks and the femurs were prepared using standard histological procedures. The tissue reactions were graded from none to severe. At 4 weeks both materials showed slight to moderate reactions, characterized by the presence of fibrous tissue interposition and inflammatory cells. At 12 weeks, bone healing had occurred, despite the persistence of some fibrous tissue interposition, and the reactions were classified as slight. At both observation periods, statistical analysis failed to show any difference between the two materials indicating that Dyract and Super EBA had similar intraosseous biocompatibility.
本研究的目的是比较新型亲水性玻璃离子水门汀Dyract与Super EBA的骨内生物相容性。将24只新西兰兔麻醉,剃去一侧腿部毛发,暴露股骨,在皮质骨板上钻两个孔。将材料装入硅橡胶载体中并植入股骨。一半兔子在植入后4周处死,另一半在12周处死,然后使用标准组织学程序制备股骨。组织反应从无到严重进行分级。4周时,两种材料均显示轻微至中度反应,其特征为存在纤维组织插入和炎性细胞。12周时,尽管仍有一些纤维组织插入,但已发生骨愈合,反应分类为轻微。在两个观察期,统计分析均未显示两种材料之间有任何差异,表明Dyract和Super EBA具有相似的骨内生物相容性。