Ramsey C S, Snyder Q C
USAF School of Aerospace Medicine, Brooks AFB, TX, USA.
Aviat Space Environ Med. 1998 Jun;69(6):603-6.
A 46-yr-old airline captain with many exposures to altitude chamber, fighter, and airliner flight developed migraine-type headaches after exposure to cabin altitudes above 6,000 feet. He had no prior history of chronic headaches or migraine. Symptoms began within days of starting pravastatin for hypercholesterolemia, but had not occurred during 4 yr of treatment with lovastatin. Headache intensity related directly to increasing pressure altitudes above 6,000 ft for periods of time greater than 45 min. Descent below 5,000 ft cabin altitudes relieved headaches. Exposure to barometric pressure changes has been associated with migraine headache. Vascular headaches are also a prominent feature of acute mountain sickness. Although the HMG-CoA reductase inhibitors are reported to be associated with increased occurrence of headache, the mechanism is poorly understood. Migraine headaches may be triggered in previously asymptomatic individuals by unique combinations of trigger factors. However, there have been no prior reports of migraine headaches triggered by the combined exposure to pravastatin and reduced barometric pressure.
一名46岁的航空公司机长，多次进入高空舱、驾驶战斗机和客机飞行，在暴露于高于6000英尺的机舱高度后出现偏头痛样头痛。他既往无慢性头痛或偏头痛病史。症状在开始服用普伐他汀治疗高胆固醇血症数天内出现，但在服用洛伐他汀治疗的4年期间未发生。头痛强度与在高于6000英尺的压力高度下持续超过45分钟直接相关。机舱高度降至5000英尺以下可缓解头痛。暴露于气压变化与偏头痛有关。血管性头痛也是急性高山病的一个突出特征。虽然据报道HMG-CoA还原酶抑制剂与头痛发生率增加有关，但其机制尚不清楚。偏头痛可能由多种触发因素的独特组合在以前无症状的个体中引发。然而，此前尚无关于普伐他汀与气压降低联合暴露引发偏头痛的报道。
