Department of Public Health Science, Seoul National University, Seoul, Republic of Korea.
Department of Bioconvergence Engineering, Dankook University, Gyeonggi-do, Republic of Korea.
Sci Adv. 2023 Oct 27;9(43):eadg6194. doi: 10.1126/sciadv.adg6194.
An extensive evaluation of disease occurrence after statin use based on a "hypothesis-free" approach remains scarce. To examine the effect of statin use on the potential risk of developing diseases, a propensity score-matched cohort study was executed using data from the National Sample Cohort in South Korea. A total of 7847 statin users and 39,235 nonstatin users were included in the final analysis. The period of statin use was defined as our main time-dependent exposure and was divided into three periods: current, recent, and past. The main outcomes were defined as new-onset diseases with ≥100 events based on the International Statistical Classification of Diseases, 10th Revision. We calculated the adjusted hazard ratios and 95% confidence intervals (CIs) using Cox regression. We found that statin use significantly increased the risk of developing iron deficiency anemia up to 5.04 times (95% CI, 2.11 to 12.03). Therefore, the iron levels of patients using statins should be monitored carefully.
基于“无假设”方法，对他汀类药物使用后疾病发生情况进行广泛评估的相关研究仍然较少。为了研究他汀类药物使用对潜在疾病风险的影响，本研究使用来自韩国国家样本队列的数据进行了倾向评分匹配队列研究。最终分析共纳入了 7847 例他汀类药物使用者和 39235 例非他汀类药物使用者。他汀类药物使用时间被定义为我们主要的时变暴露，并分为三个时期：当前、近期和过去。主要结局是根据国际疾病分类，第 10 次修订版，≥100 例新发病例定义的疾病。我们使用 Cox 回归计算了调整后的危险比和 95%置信区间（CI）。结果发现，他汀类药物的使用使缺铁性贫血的发病风险显著增加了 5.04 倍（95%CI，2.11 至 12.03）。因此，应密切监测使用他汀类药物患者的铁水平。
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