Martin B A, Cooper R M, Parikh S V
ECT Service, Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
J ECT. 1998 Jun;14(2):99-108.
Propofol is a nonbarbiturate anesthetic induction agent known to have anti-convulsant properties. When used as an anesthetic for electroconvulsive therapy (ECT), it can reduce seizure duration to a significant degree, which may not be fully appreciated. A case is presented in which propofol caused a 63.1% reduction in mean seizure duration compared with preceding and subsequent treatments with thiopental anesthesia. The literature on the use of propofol for ECT was reviewed with specific reference to its effect on seizure duration and any evidence of superiority to the barbiturate induction agents. It is concluded that propofol may have only very circumscribed indications as an anesthetic for ECT. If used, psychiatrists and anesthetists must be aware of its potency as an anticonvulsant.
丙泊酚是一种已知具有抗惊厥特性的非巴比妥类麻醉诱导剂。当用作电休克治疗（ECT）的麻醉剂时，它可在很大程度上缩短癫痫发作持续时间，而这一点可能未得到充分认识。本文报告了一例病例，与之前和之后使用硫喷妥钠麻醉的治疗相比，丙泊酚使平均癫痫发作持续时间减少了63.1%。回顾了关于丙泊酚用于ECT的文献，特别提及了其对癫痫发作持续时间的影响以及任何优于巴比妥类诱导剂的证据。得出的结论是，丙泊酚作为ECT的麻醉剂可能仅具有非常有限的适应症。如果使用，精神科医生和麻醉师必须意识到其作为抗惊厥剂的效力。
