Onodera H, Mitsumori K, Yasuhara K, Takegawa K, Takahashi M
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1997(115):99-106.
A 13-week subchronic oral toxicity study of phaffia colour was performed in both sexes of F344 rats by feeding of CRF-1 powder diet containing 0, 0.2, 0.6, 1.7 and 5%. Rats were randomly divided into 5 groups, each consisting of 10 males and 10 females. No animals died during the administration period. There were no treatment-related changes in body weight gain, hematological and blood biochemical examination. No treatment-related histopathological changes were also observed in any dosed groups. These findings indicate that the treatment of 5% phaffia colour in diet for 13 weeks does not cause any toxicological changes in rats.
采用含0%、0.2%、0.6%、1.7%和5%法夫酵母色素的CRF - 1粉末饲料，对F344大鼠雌雄两性进行了为期13周的亚慢性经口毒性研究。大鼠被随机分为5组，每组由10只雄性和10只雌性组成。给药期间无动物死亡。体重增加、血液学和血液生化检查未出现与处理相关的变化。在任何给药组中也未观察到与处理相关的组织病理学变化。这些结果表明，在饲料中添加5%法夫酵母色素处理13周不会对大鼠造成任何毒理学变化。
