Tang J, Yuan J, Hao H
Department of Neurology, First Affiliated Hospital of Beijing Medical University, China.
Chin Med J (Engl). 1997 Sep;110(9):698-700.
To examine the relationship between antibodies to acetylcholinesterase and myasthenic syndrome.
Serum class specific antibodies to acetylcholinesterase and acetylcholine receptor were prepared with solid phase enzyme-linked immunosorbent assay in 51 patients with myasthenic syndrome, 31 controls with other neurological diseases (diseased controls) and 44 normal controls.
The positive rate of anti-acetylcholinesterase antibody in patients with myasthenic syndrome was 25%, while the results of the other two control groups were negative. Furthermore, the positive rate in patients without myasthenia gravis was 45%, which was much higher than that (13%) in those with myasthenic gravis.
Anti-acetylcholinesterase antibody may play a role in the pathogenesis of myasthenic syndrome.
研究乙酰胆碱酯酶抗体与肌无力综合征之间的关系。
采用固相酶联免疫吸附测定法，检测51例肌无力综合征患者、31例其他神经系统疾病患者（疾病对照组）及44例正常对照者血清中乙酰胆碱酯酶和乙酰胆碱受体的类别特异性抗体。
肌无力综合征患者抗乙酰胆碱酯酶抗体阳性率为25%，其他两组对照组结果均为阴性。此外，无重症肌无力患者的阳性率为45%，远高于重症肌无力患者的阳性率（13%）。
抗乙酰胆碱酯酶抗体可能在肌无力综合征的发病机制中起作用。
