Marrott P K, Ruttley M S, Winterbottam J T, Muir J R
Eur J Cardiol. 1976 Sep;4(3):303-12.
The acute electrophysiological and hemodynamic effects of intravenous disopyramide (1.5 mg/kg body weight) were studied in 12 patients with suspected coronary artery disease. Plasma levels of disopyramide were monitored. Disopyramide delayed conduction within the His-Purkinje system and increased the effective refractory period of the atrium. Conduction within the AV node and its refractory period, however, was not significantly altered by the drug. The corrected Q-T interval was significantly increased. Disopyramide increased systemic arterial pressure and slightly raised the left ventricular end diastolic pressure. Heart rate, cardiac and stroke index were unaltered. Peak mean levels of disopyramide were reached 5 minutes after the injection of the drug.
在12例疑似冠心病患者中研究了静脉注射双异丙吡胺（1.5毫克/千克体重）的急性电生理和血流动力学效应。监测了双异丙吡胺的血浆水平。双异丙吡胺使希氏-浦肯野系统内的传导延迟，并增加了心房的有效不应期。然而，该药物对房室结内的传导及其不应期没有显著改变。校正后的Q-T间期显著延长。双异丙吡胺增加了体循环动脉压，并使左心室舒张末期压力略有升高。心率、心输出量和每搏输出量指数未改变。注射药物后5分钟达到双异丙吡胺的平均峰值水平。
