Opravil M, Rickenbach M, Ledergerber B
Abteilung Infektionskrankheiten und Spitalhygiene, Universitätsspital, Zürich.
Ther Umsch. 1998 May;55(5):329-34.
The prospective Swiss HIV Cohort Study (SHCS) documents since 1988 epidemiological, clinical and laboratory data of HIV-infected participants. Until the end of 1997, 9447 patients with a total follow-up of 25,584 patient-years have been included. The proportion of women is 27.3% and is rising. The proportion of heterosexually infected patients has been rising since 1992, this group was with 35.6% in 1997 the most frequent transmission category within the newly registered participants. The SHCS is representative for Switzerland since 73% of the 5532 nationwide registered AIDS cases are included in the study. Recently, the SHCS data could demonstrate an impressive reduction in morbidity and mortality due to the improvement in therapy and prophylaxis. The SHCS also serves as a basis for large multicenter studies that aim to evaluate new prophylactic treatments or new antiretroviral strategies. By introducing uniform guidelines for the diagnosis and the treatment of HIV infection, the SHCS has contributed significantly to the high quality of patient care, a goal that must be maintained and further improved in the future. Also important is the recognition of acute HIV infections because early treatment of such patients holds the promise to substantially improve the clinical course.
瑞士前瞻性HIV队列研究（SHCS）自1988年起记录HIV感染参与者的流行病学、临床和实验室数据。截至1997年底，已纳入9447例患者，总随访时间为25584患者年。女性比例为27.3%，且呈上升趋势。自1992年以来，异性传播感染患者的比例一直在上升，该组在1997年新登记参与者中是最常见的传播类别，占35.6%。由于瑞士全国5532例登记艾滋病病例中的73%被纳入该研究，因此SHCS对瑞士具有代表性。最近，SHCS数据显示，由于治疗和预防措施的改善，发病率和死亡率显著降低。SHCS还为旨在评估新的预防性治疗或新的抗逆转录病毒策略的大型多中心研究提供了基础。通过引入HIV感染诊断和治疗的统一指南，SHCS对高质量的患者护理做出了重大贡献，这一目标在未来必须保持并进一步改善。识别急性HIV感染也很重要，因为对此类患者进行早期治疗有望显著改善临床病程。
