Cozzani E, Parodi A, Rebora A
Department of Dermatology, University of Genoa, Italy.
J Eur Acad Dermatol Venereol. 1998 May;10(3):233-6.
Patients with pemphigus may produce antibodies against molecules other than the classical transmembranal ones. Recently, for example antibodies to 230 kDa antigens have been found in association with antibodies to intercellular substance. To better understand their prevalence, clinical correlates and prognostic significance of bands other than 130 and 160 kDa, we studied 67 pemphigus sera. About one-fourth of patients revealed multiple heterogeneous bands and 13% the 230 kDa band. When challenged with the recombinant protein rBP55, the carbossiterminal portion of bullous pemphigoid major antigen, all 230 kDa-positive-sera proved negative. Caution is to be recommended in interpreting pemphigus sera with a band migrating at the 230 kDa level.
天疱疮患者可能会产生针对经典跨膜分子以外的其他分子的抗体。例如，最近发现针对230 kDa抗原的抗体与细胞间物质抗体相关。为了更好地了解130和160 kDa以外条带的患病率、临床相关性和预后意义，我们研究了67份天疱疮血清。约四分之一的患者显示出多条异质条带，13%的患者显示出230 kDa条带。当用重组蛋白rBP55（大疱性类天疱疮主要抗原的羧基末端部分）进行检测时，所有230 kDa阳性血清均呈阴性。在用在230 kDa水平迁移的条带来解释天疱疮血清时应谨慎。
