Mukherjee A K, Ghosal S K, Maity C
Department of Biochemistry, Burdwan Medical College, India.
Toxicon. 1998 Apr;36(4):657-64. doi: 10.1016/s0041-0101(97)00055-x.
In the present investigation, it was found that oral supplementation of graded amounts of vitamin E to volunteers increased the alpha-tocopherol content of the erythrocytes and decreased the susceptibility of the latter to the hemolytic action of cobra and viper venoms. Further, exogenous addition of graded amounts of alpha-tocopherol to the red cells, prior to the addition of either venoms, minimizes the venom-induced lysis and erythrocyte phospholipid splitting. It may thus be inferred that vitamin E, a fat-soluble antioxidant, plays an important role in reducing the hemolytic action of cobra and viper venoms.
在本次研究中发现，给志愿者口服不同剂量的维生素E会增加红细胞中α-生育酚的含量，并降低红细胞对眼镜蛇毒和蝰蛇毒溶血作用的敏感性。此外，在加入任何一种毒液之前，向红细胞中外源添加不同剂量的α-生育酚，可使毒液诱导的细胞溶解和红细胞磷脂分解减至最小。因此可以推断，脂溶性抗氧化剂维生素E在降低眼镜蛇毒和蝰蛇毒的溶血作用中起重要作用。
