Hiçsönmez G, Cetin M, Tunç B, Tuncer A M, Gümrük F, Yenicesu I
Department of Pediatric Hematology, Ihsan, Dogramaci Children's Hospital, Hacettepe University, Ankara, Turkey.
Leuk Lymphoma. 1998 May;29(5-6):617-23. doi: 10.3109/10428199809050922.
High-dose methylprednisolone (HDMP) which can induce--differentiation and -apoptosis of myeloid leukemic cells has been shown to be very effective in the treatment of extramedullary infiltration (EMI) of children with acute myeloblastic leukemia (AML). In the present study 2 children with chronic myelomonocytic leukemia (CMML) who had pleural effusions were given a single daily dose of oral methylprednisolone (20 mg/kg or 30 mg/kg). In addition to dramatic improvement of respiratory symptoms, pleural effusions disappeared in four days in both patients possibly due to apoptotic cell death induced by HDMP treatment. Further studies are needed to determine whether high-dose corticosteroids are also effective on the resolution of pleural effusions associated with other malignant disease.
高剂量甲基泼尼松龙（HDMP）可诱导髓系白血病细胞分化和凋亡，已被证明在治疗急性髓性白血病（AML）患儿的髓外浸润（EMI）方面非常有效。在本研究中，2名患有胸腔积液的慢性粒单核细胞白血病（CMML）患儿每日口服一次甲基泼尼松龙（20mg/kg或30mg/kg）。除了呼吸症状显著改善外，两名患者的胸腔积液均在四天内消失，这可能是由于HDMP治疗诱导的凋亡细胞死亡。需要进一步研究以确定高剂量皮质类固醇对与其他恶性疾病相关的胸腔积液消退是否也有效。
