Kondo H
Department of Medicine, Shimizu Kosei Hospital, Japan.
Acta Haematol. 1998;99(4):200-5. doi: 10.1159/000040839.
We investigated the haematological effects of a massive dose of oral cobalamin (vitamin B12) on patients with cobalamin deficiency anaemia who had severe anaemia with a few neurological impairments and found that oral treatment was almost as effective as conventional injection therapy. The recovery of haematological indices with oral cobalamin preparations was slightly slower than with parenteral preparations, although the subjective symptoms disappeared soon after the start of therapy. The results of this study indicate that oral treatment keeps the cobalamin body stores satisfactorily filled and might be useful for older patients in whom injecting might be difficult.
我们研究了大剂量口服钴胺素（维生素B12）对患有钴胺素缺乏性贫血且伴有严重贫血和一些神经功能障碍的患者的血液学影响，发现口服治疗几乎与传统注射疗法一样有效。尽管治疗开始后主观症状很快消失，但口服钴胺素制剂时血液学指标的恢复比胃肠外给药制剂略慢。本研究结果表明，口服治疗能使体内钴胺素储备得到满意补充，可能对难以进行注射的老年患者有用。
