Tanaka M, Kimura R, Matsutani A, Zaitsu K, Oka Y, Oizumi K
First Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
Acta Haematol. 1998;99(4):221-3. doi: 10.1159/000040843.
A case report of simultaneous presentation of chronic myelogenous leukemia (CML) and multiple myeloma (MM) in a 72-year-old female is described. Our case was typical of Ph1-positive and chimeric bcr-abl messenger RNA-positive CML. Furthermore, a marked IgG (kappa-type) paraproteinemia was present. Fluorescence in situ hybridization showed that 97% of marrow nucleated cells were positive for bcr-abl fusion signal, when myeloma cells in the bone marrow amounted to 19.0%. In the literature survey, 4 similar cases with coexistence of CML and MM have been identified.
本文描述了一名72岁女性同时患有慢性粒细胞白血病（CML）和多发性骨髓瘤（MM）的病例报告。我们的病例是典型的Ph1阳性和嵌合型bcr-abl信使核糖核酸阳性的慢性粒细胞白血病。此外，还存在明显的IgG（κ型）副蛋白血症。荧光原位杂交显示，当骨髓中的骨髓瘤细胞占19.0%时，97%的骨髓有核细胞bcr-abl融合信号呈阳性。在文献检索中，已发现4例慢性粒细胞白血病和多发性骨髓瘤共存的类似病例。
