硝酸异山梨酯气雾剂与硝酸甘油舌下片的疗效、安全性及心脏血流动力学效应比较
[Comparative efficacy, safety, cardio-hemodynamic effects of isosorbide dinitrate (ID) aerosol and sublingual tablets of nitroglycerin].
作者信息
Ol'binskaia L I, Sizova Zh M, Ushakova A V
出版信息
Ter Arkh. 1998;70(5):69-72.
AIM
To study efficacy, safety, cardiohemodynamic effects of ID aerosol--isoket--for relief of anginal attacks and their prevention in long-term treatment.
MATERIALS AND METHODS
15 patients with ischemic heart disease suffering from stable angina class II-III. Isoket was tried for efficacy, tolerance, hemodynamic parameters, morphofunctional status of the heart, exercise tolerance.
RESULTS
Isoket aerosol in a dose 1.25 mg as a single oral spray arrested anginal attacks in all the patients. In long-term regimens good antianginal effect was achieved in 60% of cases. The ID aerosol produces a fast antianginal effect, improves morphofunctional cardiac parameters and exercise tolerance.
CONCLUSION
Isoket spray is effective and safe antianginal drug.
目的
研究异舒吉气雾剂（isoket）在缓解心绞痛发作及其长期治疗预防方面的疗效、安全性和心脏血流动力学效应。
材料与方法
15例患有稳定型II - III级心绞痛的缺血性心脏病患者。对异舒吉进行疗效、耐受性、血流动力学参数、心脏形态功能状态、运动耐量方面的试验。
结果
单次口服喷雾剂量为1.25mg的异舒吉气雾剂可使所有患者的心绞痛发作停止。在长期治疗方案中，60%的病例取得了良好的抗心绞痛效果。异舒吉气雾剂产生快速抗心绞痛作用，改善心脏形态功能参数和运动耐量。
结论
异舒吉喷雾剂是一种有效且安全的抗心绞痛药物。
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