Traut W, Wollert B
Institut für Biologie, Medizinische Universität zu Lübeck, Germany.
Genome. 1998 Apr;41(2):289-94. doi: 10.1139/g98-015.
The sex chromosomes of the Megaselia scalaris wild-type strain Wien are homomorphic. We studied a roughly 1.8 kb X/Y DNA segment of this strain. It includes, at one end, the first part of a coding sequence for a protein of the vespid antigen 5 family. Molecular differentiation between the X and Y chromosomes has commenced, but homology, even of short DNA stretches, is still assessable beyond doubt. The most conspicuous differences between the X and the homologous Y segment were insertions/deletions in the noncoding region: among them, deletions, a duplication, and an insertion of a mobile element. These structural changes grossly disrupted homology. In comparison, base substitutions, though more numerous, contributed little to the differentiation of the X/Y DNA segment.
黑腹果蝇野生型品系维也纳的性染色体是同形的。我们研究了该品系一段约1.8 kb的X/Y DNA片段。它一端包含黄蜂抗原5家族一种蛋白质编码序列的第一部分。X和Y染色体之间的分子分化已经开始，但即使是短DNA片段的同源性仍然可以明确评估。X与同源Y片段之间最明显的差异是非编码区的插入/缺失：其中包括缺失、一个重复以及一个移动元件的插入。这些结构变化严重破坏了同源性。相比之下，碱基替换虽然数量更多，但对X/Y DNA片段的分化贡献不大。
