Venz S, Hierholzer J, Keske U, Friedrichs R, Schröder R, Siewert C, Hosten N, Felix R
Strahlenklinik und Poliklinik, Virchow-Klinikum, Humboldt-Universität, Berlin.
Aktuelle Radiol. 1998 May;8(3):119-24.
To evaluate the use of contrast-enhanced T1-weighted images with fat suppression (T1FS) to improve the contrast-to-noise ratio of renal cancer and renal parenchyma as well as perirenal fat.
25 patients with histologically proven unilateral renal cancer after nephrectomy were examined before surgery. In addition to plane and contrast-enhanced T1-weighted as well as T2-weighted spin-echo images, all patients had T1 FS immediately after administration of Gd-DTPA in two planes. The contrast-to-noise ratio was calculated using circular regions-of-interest which outlined the tumor, the renal parenchyma, pyelon, and the perirenal fat.
T1 FS significantly improved the contrast-to-noise ratio of renal cancer and renal parenchyma compared to all conventional spinecho sequences (p < 0.001; Wilcoxon-Test). Compared to contrast-enhanced T1-weighted images without fat-suppression T1 FS yielded a higher CNR of the tumor, the perirenal fat and the pyelon. Another advantage was the absence of the chemical-shift artifact which is mostly pronounced in T2-weighted images and a reduced number of observed artifacts due to breathing.
T1 FS should replace conventional contrast-enhanced T1-weighted spin-echo images in the work-up of renal cancer using MRI.
评估使用脂肪抑制的对比增强T1加权成像（T1FS）来提高肾癌、肾实质以及肾周脂肪的对比噪声比。
对25例经组织学证实为单侧肾癌且已接受肾切除术的患者在手术前进行检查。除了常规平面成像、对比增强T1加权以及T2加权自旋回波图像外，所有患者在静脉注射钆喷酸葡胺（Gd-DTPA）后立即在两个平面进行T1FS成像。使用勾勒出肿瘤、肾实质、肾盂以及肾周脂肪的圆形感兴趣区来计算对比噪声比。
与所有传统自旋回波序列相比，T1FS显著提高了肾癌和肾实质的对比噪声比（p < 0.001；Wilcoxon检验）。与未进行脂肪抑制的对比增强T1加权图像相比，T1FS使肿瘤、肾周脂肪和肾盂的对比噪声比更高。另一个优点是不存在化学位移伪影（该伪影在T2加权图像中最为明显）以及因呼吸导致的观察到的伪影数量减少。
在使用MRI对肾癌进行检查时，T1FS应取代传统的对比增强T1加权自旋回波图像。
