Garcia A, Johnson H, Srivastava D K, Jayawardene D A, Wehr D R, Webster R G
Department of Virology and Molecular Biology, St. Jude Children's Research Hospital Memphis, TN 38105, USA.
Avian Dis. 1998 Apr-Jun;42(2):248-56.
The control and eventual eradication of H5N2 influenza virus from domestic poultry in Mexico is dependent on the use of avian influenza (AI) vaccine strategies. This study was performed to determine the amount of hemagglutinin (HA) antigen required to control the signs of disease from a highly pathogenic H5N2 influenza virus (A/Chicken/ Queretaro/19/95) and the amount of antigen required to prevent shedding of virus from vaccinated birds. Six commercial inactivated water in oil H5N2 vaccines available in Mexico were compared with standardized vaccines to assess their efficacy. The amount of HA required to prevent the signs of disease from A/Chicken/Queretaro/19/95 influenza virus was approximately 0.4 microgram per dose. Each of the six commercially available vaccines prevented disease signs, and half of the vaccines significantly reduced viral shedding from vaccinated birds. There is a need for standardization of AI virus vaccine, and the antigen content should be increased in some of the commercially available AI vaccines in Mexico.
在墨西哥，在家禽中控制并最终根除H5N2流感病毒依赖于禽流感（AI）疫苗策略的使用。开展本研究以确定控制高致病性H5N2流感病毒（A/鸡/克雷塔罗/19/95）所致疾病体征所需的血凝素（HA）抗原量，以及防止接种疫苗的禽类排出病毒所需的抗原量。将墨西哥市售的六种商业化油包水型H5N2灭活疫苗与标准化疫苗进行比较，以评估其效力。预防A/鸡/克雷塔罗/19/95流感病毒所致疾病体征所需的HA量约为每剂0.4微克。六种市售疫苗均能预防疾病体征，且其中一半疫苗显著减少了接种疫苗禽类的病毒排出。需要对AI病毒疫苗进行标准化，墨西哥市售的一些AI疫苗应增加抗原含量。
