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以继发性佩吉特骨肉瘤为代表的肱骨近端恶性肿瘤的手术治疗。

The operative management of a malignant proximal humerus tumor represented by secondary Paget's osteosarcoma.

作者信息

Benthien J P, Fuhrmann R, Venbrocks R

机构信息

Department of Orthopaedic Surgery, Friedrich-Schiller-University Jena, Eisenberg, Germany.

出版信息

J Cancer Res Clin Oncol. 1998;124(5):270-4. doi: 10.1007/s004320050165.

Abstract

PURPOSE

Malignant tumors at the proximal humerus are an operative challenge. Radical removal is a principal of tumor surgery but as much functionality as possible should be retained. These conditions often conflict so a compromise has to be reached. This paper proposes a solution to this dilemma, introducing an operative approach, with a new modular prosthesis, to a secondary Paget's osteosarcoma in the proximal humerus.

METHODS AND RESULTS

A recently developed humerus modular prosthesis is described, which has been implanted into a patient with Paget's osteosarcoma. In these, mostly elderly, patients, successful operative therapy should combine radical removal with early mobilization. Paget's osteosarcoma is a recognized complication of the disease, and its prognosis is poor. In our patient, the implanted humerus prosthesis allowed a limb-saving procedure to be combined with radical removal of the tumor and postoperative early mobilization. A 3-month follow-up yielded good results with no recurrence of the disease and the patient had satisfactory movement. She was able to resume normal daily life shortly after the operation.

CONCLUSION

Implantation of a modular prosthesis of the humerus may allow radical removal of a malignant tumor in that area while achieving early motion. In the literature, amputation is often advocated, as radical treatment with chemotherapy is not a successful option in this elderly patient group. We think the alternative use of a modular prosthesis of the humerus is possible in selected cases. We have encountered no other case in the literature where a limb-saving procedure attempts to preserve as much functionality as possible in Paget's osteosarcoma.

摘要

目的

肱骨近端的恶性肿瘤是手术中的一项挑战。根治性切除是肿瘤手术的一项原则,但应尽可能保留功能。这些情况常常相互冲突,因此必须达成妥协。本文提出了一种解决这一困境的方法,介绍了一种针对肱骨近端继发性佩吉特骨肉瘤的手术方法及一种新型模块化假体。

方法与结果

描述了一种最近开发的肱骨模块化假体,该假体已植入一名佩吉特骨肉瘤患者体内。对于这些大多为老年的患者,成功的手术治疗应将根治性切除与早期活动相结合。佩吉特骨肉瘤是该疾病公认的一种并发症,其预后较差。在我们的患者中,植入的肱骨假体使得保肢手术能够与肿瘤的根治性切除及术后早期活动相结合。3个月的随访结果良好,疾病未复发,患者的活动情况令人满意。术后不久她就能恢复正常的日常生活。

结论

植入肱骨模块化假体可以在实现早期活动的同时对该部位的恶性肿瘤进行根治性切除。在文献中,常提倡截肢,因为在这个老年患者群体中,化疗的根治性治疗并非成功的选择。我们认为在某些特定病例中,使用肱骨模块化假体作为替代方案是可行的。在文献中,我们未遇到其他在佩吉特骨肉瘤保肢手术中试图尽可能保留功能的病例。

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