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在先前学习的威斯康星卡片分类测验(WCST)执行过程中,随着持续输注配体,单光子发射计算机断层扫描(SPECT)脑血流发生变化。

SPECT brain blood flow changes with continuous ligand infusion during previously learned WCST performance.

作者信息

Tien A Y, Schlaepfer T E, Orr W, Pearlson G D

机构信息

Department of Mental Hygiene, Johns Hopkins School of Public Health, Baltimore, MD, USA.

出版信息

Psychiatry Res. 1998 Apr 10;82(1):47-52. doi: 10.1016/s0925-4927(98)00003-1.

DOI:10.1016/s0925-4927(98)00003-1
PMID:9645550
Abstract

Performance of the Wisconsin Card Sorting Test (WCST) and related brain-activation patterns reflect both task learning and execution. Normal subjects learned the WCST prior to performance during slow SPECT ligand infusion. Blood flow increased in bilateral inferior frontal, right middle and inferior parietal cortices. Activity decreased in hippocampi, temporal cortex, anterior cingulate and caudate.

摘要

威斯康星卡片分类测试(WCST)的表现及相关的脑激活模式反映了任务学习和执行情况。正常受试者在慢速单光子发射计算机断层扫描(SPECT)配体注入期间进行WCST之前就已学会该测试。双侧额下回、右侧顶叶中部和下部皮质的血流增加。海马体、颞叶皮质、前扣带回和尾状核的活动减少。

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