Fisher J, Mantz F, Calkins W G
Gastroenterology. 1976 Nov;71(5):385-8.
Three cases of acute, free perforation of the colon in Crohn's disease are described and their clinical and pathological features are detailed. Colonic perforation in Crohn's disease bears no definite relationship to obstruction or adrenocorticosteroid therapy. It may occur with or without toxic megacolon, and pathological study has not thus far suggested a common pathogenetic mechanism. Although free perforation has been considered to be extremely rare in Crohn's colitis, it is likely that this complication is more common than previously believed.
本文描述了3例克罗恩病患者发生的急性结肠游离穿孔，并详细阐述了其临床和病理特征。克罗恩病中的结肠穿孔与肠梗阻或肾上腺皮质激素治疗并无明确关联。它可伴有或不伴有中毒性巨结肠发生，且迄今为止的病理研究尚未提示存在共同的发病机制。尽管结肠游离穿孔在克罗恩结肠炎中被认为极为罕见，但这种并发症可能比之前认为的更为常见。
