Deschner E E, Goldstein M J, Melamed M R, Sherlock P
Gastroenterology. 1976 Nov;71(5):832-4.
The influence of an altered environment of the cellular kinetics and histological appearance of ileal mucosa used as a urinary bladder was investigated in a patient with a conduit of 1 year and 7 months' duration. After injection of 10 mc of 3H-TdR, multiple biopsies were taken spanning a 3-day period. No increase in inflammatory cell numbers was seen and villous atrophy was minimal. A generation time or total cell cycle time of 36 hr was observed, with a G1 phase of 22 hr and an S phase of 11 hr. At 1 hr 2.4 3H-TdR-labeled cells per crypt column and a mitotic index of 1.4% were obtained. The complet labeled mitosis curve obtained on the epithelial cells of the 19-month-old ileal conduit mucosa demonstrated a retention of the kinetics and histological characteristics of normal ileal mucosa, contrary to previously documented findings.
在一名使用回肠黏膜作为膀胱已有1年7个月的患者中，研究了改变的环境对用作膀胱的回肠黏膜细胞动力学和组织学外观的影响。注射10微居里的3H-胸腺嘧啶核苷后，在3天的时间内进行了多次活检。未观察到炎症细胞数量增加，绒毛萎缩也很轻微。观察到的代时或总细胞周期时间为36小时，G1期为22小时，S期为11小时。在1小时时，每个隐窝柱有2.4个3H-胸腺嘧啶核苷标记的细胞，有丝分裂指数为1.4%。在19个月大的回肠导管黏膜上皮细胞上获得的完整标记有丝分裂曲线表明，其保留了正常回肠黏膜的动力学和组织学特征，这与先前记录的结果相反。
