庚酸奋乃静注射液对精神分裂症女性和男性血浆中催乳素水平的影响。
Effects of perphenazine enanthate injections on prolactin levels in plasma from schizophrenic women and men.
作者信息
Lindholm H, Gullberg B, Ohman A, Sedvall G
出版信息
Psychopharmacology (Berl). 1978 Apr 14;57(1):1-4. doi: 10.1007/BF00426949.
PMID:96459
Abstract
Levels of prolactin (PRL) in plasma were determined in schizophrenic women and men after i.m. injections of 50-150 mg perphenazine enanthate (PE). In both sexes PRL levels increased dose-dependently. In men the effect was significant for 2 and in women for 9 days. Biperiden treatment did not influence the effect of PE on the PRL levels. The data support the view that clinically used doses of PE induce a small but significant blockade of central dopamine receptors.
摘要
对精神分裂症女性和男性肌肉注射50 - 150毫克庚酸奋乃静（PE）后，测定其血浆中催乳素（PRL）水平。在男女两性中，PRL水平均呈剂量依赖性升高。在男性中，这种效应在2天内显著；在女性中，在9天内显著。安坦治疗不影响PE对PRL水平的作用。这些数据支持以下观点：临床使用剂量的PE会引起中枢多巴胺受体的轻微但显著的阻断。
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