Osuna E, Pérez-Cárceles M D, Alvarez M V, Noguera J, Luna A
Department of Forensic Medicine, University of Murcia, Spain.
Int J Legal Med. 1998;111(4):173-6. doi: 10.1007/s004140050143.
In clinical practice several biochemical markers are used for the diagnosis of myocardial infarction. Because of its extremely high specificity for myocardial damage, cardiac troponin I (cTn I) is frequently used. The aim of this study was to evaluate the diagnostic efficacy of postmortem cTn I determinations in pericardial fluid and serum and to compare these results with other biochemical markers and with structural findings used to diagnose acute myocardial ischaemia. We studied 89 cadavers with a mean age of 51.38 +/- 2.04 (SD 19.27 years). Cases were allocated to 1 of 4 diagnostic groups depending on the probable intensity of myocardial damage and cause of death. In pericardial fluid we obtained statistically significant differences for the four biochemical parameters, while in serum myosin heavy chains and myoglobin showed statistically significant differences. The highest levels of biochemical markers in pericardial fluid were observed in subjects who had died from definite myocardial infarction.
在临床实践中，有几种生化标志物用于诊断心肌梗死。由于心肌肌钙蛋白I（cTn I）对心肌损伤具有极高的特异性，因此经常被使用。本研究的目的是评估心包液和血清中死后cTn I测定的诊断效力，并将这些结果与其他生化标志物以及用于诊断急性心肌缺血的结构发现进行比较。我们研究了89具平均年龄为51.38±2.04（标准差19.27岁）的尸体。根据心肌损伤的可能强度和死亡原因，将病例分为4个诊断组之一。在心包液中，我们获得了四种生化参数的统计学显著差异，而在血清中，肌球蛋白重链和肌红蛋白显示出统计学显著差异。死于明确心肌梗死的受试者心包液中生化标志物水平最高。
