Katz R J, Carroll B J
Psychopharmacology (Berl). 1978 Apr 14;57(1):39-42. doi: 10.1007/BF00426955.
The centrally active inhibitors of phenylethanolamine-N-methyl transferase (PNMT; E.C. 2.1.1.28), the terminal enzyme for epinephrine biosynthesis in the brain, produced dose-related decreases in rats of responding for rewarding brain stimulation in adult male rats. Decreases occurred at dosages that did not produce measurable neurologic impairment. This suggests a possible role for central epinephrine-containing neurons in the maintenance of reward-mediated behaviors.
苯乙醇胺 -N-甲基转移酶（PNMT；酶编号2.1.1.28）是大脑中肾上腺素生物合成的末端酶，其中枢活性抑制剂会使成年雄性大鼠对脑刺激奖赏的反应出现与剂量相关的减少。在未产生可测量神经损伤的剂量下就出现了减少。这表明含中枢肾上腺素的神经元在维持奖赏介导行为中可能发挥作用。
