Ultrastructural changes of Candida albicans under influence of cyclosporin A.

The aim of this study was the assessment of influence of cyclosporin A on ultrastructural changes of Candida albicans in vitro. Strains of Candida albicans isolated from woman with chronic vulvovaginitis were used. At the first part of experiment MIC (minimal inhibitory concentration) of cyclosporin on Sabouraud medium was assessed. Control plates were also prepared. From plates with Candida albicans there was observed its visual growth, the yeasts were prepared for electron transmission microscopic examines. It was found that ultrastructural changes of Candida albicans cells in the presence of Cyclosporin A. In particular, the cell wall was thicker and deteriorated. The organelles were altered in varying degrees and autolysis was observed.