Rebecchi M J, Scarlata S
Department of Anesthesiology, State University of New York at Stony Brook 11794, USA.
Annu Rev Biophys Biomol Struct. 1998;27:503-28. doi: 10.1146/annurev.biophys.27.1.503.
Pleckstrin homology (PH) motifs are approximately 100 amino-acid residues long and have been identified in nearly 100 different eukaryotic proteins, many of which participate in cell signaling and cytoskeletal regulation. Despite minimal sequence homology, the three-dimensional structures are remarkably conserved. This review gives an overview of the PH domain architecture and examines the best-studied examples in an attempt to understand their function.
普列克底物蛋白同源（PH）基序约含100个氨基酸残基，已在近100种不同的真核生物蛋白质中被鉴定出来，其中许多蛋白质参与细胞信号传导和细胞骨架调节。尽管序列同源性很低，但三维结构却非常保守。本综述概述了PH结构域的结构，并研究了一些研究得较为透彻的例子，以期了解它们的功能。
