Jimidar M, Beyns I, Rome R, Peeters R, Musch G
Janssen Research Foundation, Beerse, Belgium.
Biomed Chromatogr. 1998 May-Jun;12(3):128-30. doi: 10.1002/(SICI)1099-0801(199805/06)12:3<128::AID-BMC778>3.0.CO;2-8.
A Capillary Electrophoresis method was developed and applied successfully to test the quality of different drug formulations for release and stability studies. In the method an uncoated fused-silica capillary was employed containing a phosphoric acid buffer electrolyte which was brought to pH by triethylamine. The benzalkonium chlorides (BAC-C12 and BAC-C14) present in the standard were completely separated from each other and from the peaks of the main compound. Performance results of the method in terms of system repeatability, precision and accuracy are discussed.
开发了一种毛细管电泳方法，并成功应用于测试不同药物制剂的释放和稳定性研究质量。在该方法中，使用了未涂层的熔融石英毛细管，其中含有由三乙胺调节pH值的磷酸缓冲电解质。标准品中存在的苯扎氯铵（BAC-C12和BAC-C14）彼此之间以及与主要化合物的峰完全分离。讨论了该方法在系统重复性、精密度和准确度方面的性能结果。
