Bohning D E, Shastri A, Nahas Z, Lorberbaum J P, Andersen S W, Dannels W R, Haxthausen E U, Vincent D J, George M S
Department of Radiology, Medical University of South Carolina, Charleston 29425, USA.
Invest Radiol. 1998 Jun;33(6):336-40. doi: 10.1097/00004424-199806000-00004.
The authors demonstrate the feasibility of combining transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) inside an MR scanner to noninvasively stimulate and image regional brain activity.
Echoplanar blood oxygen level dependent (BOLD)-based fMRI studies of TMS response were performed on three human volunteers inside a standard 1.5 T MR scanner using independent computer control to interleave echoplanar image acquisition and stimulation of right thumb primary motor cortex with a nonferromagnetic TMS coil.
Significant (P< 0.001) response was observed in motor cortex under the TMS coil during stimulation compared to rest, as well in auditory cortex, the latter presumably due to the loud "snap" when the coil was pulsed.
Concurrent TMS stimulation and echoplanar BOLD fMRI imaging is possible. This method has potential for tracing neural circuits with brain imaging, as well as investigating the effects of TMS.
作者证明了在磁共振成像（MR）扫描仪内将经颅磁刺激（TMS）与功能磁共振成像（fMRI）相结合以无创刺激和成像局部脑活动的可行性。
在一台标准的1.5T MR扫描仪内，对三名人类志愿者进行了基于回波平面血氧水平依赖（BOLD）的TMS反应功能磁共振成像研究，使用独立的计算机控制来交错回波平面图像采集，并使用非铁磁性TMS线圈刺激右手拇指初级运动皮层。
与静息状态相比，在刺激期间，TMS线圈下方的运动皮层观察到显著（P<0.001）反应，在听觉皮层也观察到显著反应，推测后者是由于线圈脉冲时发出的响亮“啪嗒”声所致。
同时进行TMS刺激和回波平面BOLD功能磁共振成像可行。该方法具有通过脑成像追踪神经回路以及研究TMS效应的潜力。
