Busse W W
University of Wisconsin Hospital and Clinics, Madison 53792, USA.
Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 2):S210-3; discussion S247-8.
Leukotrienes are potent pro-inflammatory mediators that appear to contribute to pathophysiologic features of asthma. For example, cysteinyl leukotrienes contract airway smooth muscle, increase microvascular permeability, stimulate mucus secretion, decrease mucociliary clearance, and appear capable of recruiting eosinophils into the airways. Segmental antigen bronchoprovocation in patients with asthma increases LTC4 concentrations in bronchoalveolar lavage fluid, which correlates with an influx of eosinophils into the airways. LTB4, in comparison, selectively affects neutrophil functions. Intratracheal instillation of LTB4 produced a selective recruitment of neutrophils into the lung. These effects suggest that leukotrienes contribute significantly to the inflammatory components of asthma.
白三烯是强效的促炎介质，似乎与哮喘的病理生理特征有关。例如，半胱氨酰白三烯可使气道平滑肌收缩，增加微血管通透性，刺激黏液分泌，降低黏液纤毛清除功能，并且似乎能够将嗜酸性粒细胞募集到气道中。哮喘患者进行节段性抗原支气管激发试验可使支气管肺泡灌洗液中LTC4浓度升高，这与嗜酸性粒细胞流入气道相关。相比之下，LTB4选择性地影响中性粒细胞功能。气管内注入LTB4可使中性粒细胞选择性地募集到肺中。这些效应表明白三烯在哮喘的炎症成分中起重要作用。
