Jazayeri A, Tsibris J C, Spellacy W N
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33606, USA.
Obstet Gynecol. 1998 Jul;92(1):61-3. doi: 10.1016/s0029-7844(98)00126-4.
To determine if umbilical cord plasma erythropoietin levels are elevated in pregnancies that continue beyond their expected date for delivery.
Erythropoietin was measured using an enzyme-linked immunosorbent assay in 124 appropriately grown newborns delivered from 37-43 weeks' gestation. Each woman had an uncomplicated labor and delivery course without evidence of fetal stress or meconium. The comparison was made between pregnancies ending at 37-40 weeks' gestation and those at 41-43 weeks' gestation.
There was no difference between the two groups in cord blood gases or Apgar scores at 1 and 5 minutes. Cord plasma erythropoietin levels were significantly higher in pregnancies delivered after 41 completed weeks' gestation (41 or more weeks: 48.0+/-7.1 mIU/mL, n=45 versus 37-40 weeks: 26.1+/-4.2 mIU/mL, n=79, P < .001). When compared with pregnancies delivered between 37 and 40 weeks, erythropoietin levels were significantly elevated in pregnancies delivered at either 41, 42, or 43 weeks' gestation.
In pregnancies reaching 41 weeks and beyond, cord plasma erythropoietin levels are significantly increased, indicating altered fetal oxygenation in some of these pregnancies. These results support the current practice of close fetal surveillance of prolonged pregnancies.
确定超过预产期分娩的孕妇脐带血浆促红细胞生成素水平是否升高。
采用酶联免疫吸附测定法，对124例孕37 - 43周分娩的发育正常的新生儿进行促红细胞生成素检测。每位产妇分娩过程顺利，无胎儿窘迫或胎粪迹象。将孕37 - 40周分娩的孕妇与孕41 - 43周分娩的孕妇进行比较。
两组新生儿出生后1分钟和5分钟时的脐血气及阿氏评分无差异。孕41周及以后分娩的孕妇，其脐带血浆促红细胞生成素水平显著更高（孕41周及以上：48.0±7.1 mIU/mL，n = 45；孕37 - 40周：26.1±4.2 mIU/mL，n = 79，P <.001）。与孕37至40周分娩的孕妇相比，孕41、42或43周分娩的孕妇促红细胞生成素水平显著升高。
在孕41周及以后的孕妇中，脐带血浆促红细胞生成素水平显著升高，表明其中部分孕妇存在胎儿氧合改变。这些结果支持了目前对过期妊娠进行密切胎儿监测的做法。
