秋水仙碱的代谢转化，IV[1]。关于秋水仙碱和秋水仙次碱与巯基化合物的相互作用。
Metabolic transformation of colchicine, IV[1]. On the interaction of colchicine and colchiceine with sulfhydryl compounds.
作者信息
Schnell E, Schönharting M, Siebert G
出版信息
Hoppe Seylers Z Physiol Chem. 1976 Apr;357(4):567-71. doi: 10.1515/bchm2.1976.357.1.567.
The interaction of colchicine and one of its metabolites, O10-demethylcolchicine (colchiceine), with sulfhydryl compounds was studied in several experimental systems. Colchiceine protects reduced glutathione from oxidation by atmospheric oxygen. Inactivation of enzymes with catalytically essential sulfhydryl groups is prevented by colchiceine. In affinity chromatographic experiments, Agarose-bound colchiceine adsorbs sulfhydryl enzymes which may be eluted specifically by SH-compounds like mercaptoethanol. No such effects are shown by colchicine. The data demonstrate a novel type of biochemical reactivity in the metabolite colchiceine with potential biological relevance.
在多个实验系统中研究了秋水仙碱及其一种代谢产物O10-去甲基秋水仙碱（秋水仙素）与巯基化合物的相互作用。秋水仙素可保护还原型谷胱甘肽不被大气中的氧气氧化。秋水仙素可防止具有催化活性必需巯基的酶失活。在亲和色谱实验中，琼脂糖结合的秋水仙素可吸附巯基酶，这些酶可用巯基乙醇等巯基化合物特异性洗脱。秋水仙碱未表现出此类作用。这些数据证明了代谢产物秋水仙素中一种具有潜在生物学相关性的新型生化反应性。
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