Lee S G, Matsuyoshi N, Ohta K, Horiguchi Y, Imamura S
Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto, 6068507 Japan.
Eur J Dermatol. 1998 Jun;8(4):280-2.
A 21-year-old woman who had been taking several kinds of analgesics to treat dysmenorrhea developed episodic attacks of a purpuric macular eruption and a burning sensation on unexposed areas of the upper chest and back where she had sustained severe sunburn eight months earlier. Target-like lesions developed on these areas after intake of Bufferin, a combination of aspirin and dialuminate. After the eruptions had abated following systemic administration of a corticosteroid agent, a challenge test was performed, using a quarter of a tablet of Bufferin. The patient developed a temporary burning sensation and a erythematous color on the previously sunburned skin. We diagnosed this case as a drug eruption due to Bufferin showing erythema exsudativium multiforme with a photo-recall-like phenomenon. In our case, skin tests would be useful to confirm the causal drug.
一名21岁女性，一直在服用多种镇痛药治疗痛经，其未暴露的上胸部和背部出现了紫癜性黄斑疹发作和烧灼感，8个月前她在这些部位遭受了严重晒伤。服用阿司匹林和双铝酸盐组合的百服宁后，这些部位出现了靶样皮损。在全身应用皮质类固醇药物后皮疹消退，进行了激发试验，使用四分之一片百服宁。患者在先前晒伤的皮肤上出现了暂时的烧灼感和红斑。我们将此病例诊断为因百服宁引起的药疹，表现为多形性渗出性红斑并伴有光回忆样现象。在我们的病例中，皮肤试验有助于确认致病药物。
