Tonev S, Vasileva S, Kadurina M
Department of Dermatology, Military Medical Academy, Sofia, Bulgaria.
J Eur Acad Dermatol Venereol. 1998 Sep;11(2):165-8.
A case of erythema multiforme-like reaction, following therapy with sulfadimethoxynum is reported in a 19-year-old male patient. Histological examination demonstrated a subepidermal bulla and direct immunofluorescence revealed linear deposition of IgA at the dermoepidermal junction. These observations illustrate that linear IgA bullous dermatosis can mimic the clinical features of erythema multiforme and suggest the possibility of drug-induced pathogenesis.
据报道，一名19岁男性患者在接受磺胺二甲氧嘧啶治疗后出现了多形红斑样反应。组织学检查显示表皮下大疱，直接免疫荧光显示IgA在真皮表皮交界处呈线性沉积。这些观察结果表明，线状IgA大疱性皮肤病可模仿多形红斑的临床特征，并提示药物诱导发病机制的可能性。
