Proudfoot A E
Serono Pharmaceutical Research Institute, 14, chemin des Aulx, 1228 Plan-les-Ouates, CH Genève.
Eur J Dermatol. 1998 Apr-May;8(3):147-57.
Basal trafficking and homing of leukocytes is controlled by a large subfamily of cytokines, the chemokines. The initiation and perpetuation of an inflammatory response is also mediated by the chemokines. The chemokine family acts through a sub-family of the seven transmembrane, G-protein-coupled receptor class. Despite the large number of chemokine proteins, several factors such as regulated expression of the ligands and their receptors, glycosoaminoglycan interactions and their signaling mechanisms introduce the required selectivity in vivo. Recently, chemokine receptors have been identified as an essential component for the infection of host cells by HIV. Chemokine receptors thus present an attractive therapeutic target for inflammatory disorders and HIV infection, and evidence for their validation using antibodies and receptor antagonists is discussed.
白细胞的基础运输和归巢由一大类细胞因子即趋化因子控制。炎症反应的启动和持续也由趋化因子介导。趋化因子家族通过七跨膜G蛋白偶联受体亚家族发挥作用。尽管趋化因子蛋白数量众多，但诸如配体及其受体的调控表达、糖胺聚糖相互作用及其信号传导机制等多种因素在体内引入了所需的选择性。最近，趋化因子受体已被确定为HIV感染宿主细胞的重要组成部分。因此，趋化因子受体是炎症性疾病和HIV感染有吸引力的治疗靶点，并讨论了使用抗体和受体拮抗剂对其进行验证的证据。
