Guerriero C, De Simone C, Tulli A
Department of Dermatology, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Roma, Italy.
Eur J Dermatol. 1998 Apr-May;8(3):167-8.
We report the case of a 40-year-old Filippino woman, with a 5-year history of a slowly spreading, painful skin lesion on her left foot. Histological examination showed a dermal, granulomatous infiltrate consisting of neutrophils, histiocytes and lymphocytes, with "sclerotic bodies" in the cytoplasm of phagocytic cells. Mycological culture revealed the presence of Phialophora verrucosa and confirmed the histopathological diagnosis of chromo-blastomycosis. Association of surgical curettage of the exuberant, infected tissue with systemic fluconazole administration gave good therapeutic results with no relevant side effects.
我们报告了一例40岁的菲律宾女性病例，其左脚有一个缓慢扩散的疼痛性皮肤病变，病史长达5年。组织学检查显示真皮有肉芽肿性浸润，由中性粒细胞、组织细胞和淋巴细胞组成，吞噬细胞胞质内有“硬化小体”。真菌培养显示存在疣状瓶霉，证实了组织病理学诊断为着色芽生菌病。对增生的感染组织进行手术刮除并给予全身性氟康唑治疗，取得了良好的治疗效果，且无相关副作用。
