九种抗真菌药物及其联合用药对疣状瓶霉的体外活性。
In vitro activities of nine antifungal drugs and their combinations against Phialophora verrucosa.
作者信息
Li Yali, Wan Zhe, Li Ruoyu
机构信息
Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China.
Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China
出版信息
Antimicrob Agents Chemother. 2014 Sep;58(9):5609-12. doi: 10.1128/AAC.02875-14. Epub 2014 Jun 30.
The in vitro activities of nine antifungal drugs and their combinations against 31 clinical and 15 environmental Phialophora verrucosa strains were tested. The MIC90/90% minimum effective concentration (MIC/MEC90) values (μg/ml) across all strains were as follows: for terbinafine, 0.25; for posaconazole, 0.5; for voriconazole, 1; for itraconazole, 2; for amphotericin B, 4; for caspofungin and micafungin, 16; and for fluconazole and flucytosine, 64. The highest synergy was shown by the combination of itraconazole plus caspofungin (with synergy against 100% of the 31 clinical strains), followed by amphotericin B plus flucytosine (45.2%) and itraconazole plus terbinafine or micafungin (25.8% or 12.9%, respectively).
测试了9种抗真菌药物及其组合对31株临床和15株环境疣状瓶霉菌株的体外活性。所有菌株的MIC90/90%最低有效浓度（MIC/MEC90）值（μg/ml）如下：特比萘芬为0.25；泊沙康唑为0.5；伏立康唑为1；伊曲康唑为2；两性霉素B为4；卡泊芬净和米卡芬净为16；氟康唑和氟胞嘧啶为64。伊曲康唑加卡泊芬净的组合显示出最高的协同作用（对31株临床菌株中的100%有协同作用），其次是两性霉素B加氟胞嘧啶（45.2%）以及伊曲康唑加特比萘芬或米卡芬净（分别为25.8%或12.9%）。
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